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Cheesy Cajun Garlic Chicken Rotini Skillet with creamy cheese sauce in a large skillet ready to serve

Cheesy Cajun Garlic Chicken Rotini Skillet

A creamy, comforting skillet dish with tender Cajun-seasoned chicken, rotini pasta, and a rich triple cheese sauce. Perfect for quick weeknight meals.
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Prep Time 10 minutes
Cook Time 20 minutes
Total Time 30 minutes
Servings: 4 portions
Course: Dinner, Main Course
Cuisine: American, Cajun
Calories: 620
Ingredients Equipment Method Notes

Ingredients
  

  • 2 boneless, skinless chicken breasts cut into bite-sized chunks
  • 12 oz rotini pasta
  • 2 tablespoons olive oil
  • 2 tablespoons Cajun seasoning
  • 1 teaspoon garlic powder
  • 1/2 teaspoon onion powder
  • Salt and pepper to taste
  • 4 cloves garlic minced
  • 1 tablespoon butter
  • 1 cup heavy cream
  • 1/2 cup chicken broth
  • 1 cup shredded mozzarella cheese freshly shredded preferred
  • 1/2 cup grated Parmesan cheese
  • 1/2 cup shredded cheddar cheese
  • Fresh parsley chopped, for garnish

Equipment

  • Large pot for pasta
  • Large skillet
  • Mixing bowl
  • Wooden spoon or spatula

Method
 

  1. Bring a large pot of salted water to a boil. Cook the rotini according to package instructions until al dente. Drain and set aside.
  2. In a large skillet, heat olive oil over medium-high heat. Toss the chicken with Cajun seasoning, garlic powder, onion powder, salt, and pepper. Add the chicken to the skillet and cook for 6 to 7 minutes until browned and fully cooked through to 165°F. Remove the chicken from the skillet and set aside.
  3. In the same skillet, melt the butter. Add the minced garlic and sauté for 1 minute until fragrant.
  4. Pour in the chicken broth and heavy cream. Bring to a gentle simmer. Stir in the mozzarella, Parmesan, and cheddar cheeses. Mix until smooth and fully melted.
  5. Add the cooked rotini and chicken back into the skillet. Toss to coat everything evenly in the cheesy Cajun garlic sauce. Let simmer for 2 to 3 minutes to meld the flavors.
  6. Garnish with fresh chopped parsley and extra cheese if desired. Serve hot.

Notes

For a vegetarian version, swap chicken for sautéed vegetables like bell peppers, zucchini, or mushrooms. Adjust Cajun seasoning to taste. Add a splash of milk or chicken broth when reheating to restore creamy texture.